If you guys read my blog, you know I’m currently obsessed with broccoli sprouts and try to use them in my salads or smoothies frequently. Not only do broccoli sprouts turn on the NRF-2 gene pathway which can turn off genes that lead to cancer, but they have shown promising benefit in being able to eradicate Helicobacter Pylori, better known as H. Pylori.
WHAT IS H. PYLORI
H. Pylori is a corkscrew shaped bacterium that affects 50% of the American population and about 1/3-2/3 of the rest of the world. This little bug is classified as a carcinogen, or cancer-causing, by the World Health Organization as well as the International Agency for Research. It is strongly linked to the development of stomach issues like gastro-esophageal reflux disease (GERD) and stomach cancer. Sadly, due to antibiotic resistance, the proton pump inhibitors and antibiotic combo given by allopathic medicine is not as effective as it once was and many patients are now failing the standard treatment. Since everyone is different, the efficacy of a particular therapy may vary with each patient, environment, genes, age, food and hygiene.
As mentioned above, the standard treatment for H pylori eradication is to administer a proton pump inhibitor, like Nexium or Prilosec. Unfortunately these medications have risks associated with them-like the new study that just showed a 25% increased risk of death after a year of use. These acid blocking agents are paired with a several antibiotics for two to three weeks.
WHY WE SHOULD ALL BE EATING BROCCOLI SPROUTS:
My very favorite, and probably the MOST natural alternative to wiping out this pesky bacteria is BROCCOLI SPROUTS! When you chew or cut the sprouts, they release a stress chemical that eventually forms sulfurophane, the potent anti tumor agent and natural antioxidant, that fights H pylori. Studies show that this biochemical appears to trigger cells in the body, including the gastrointestinal tract, to produce enzymes that protect against free radical damage and inflammation.
In a small pilot study published in 2009 in Cancer Prevention Research, the researchers found that eating 2.5 ounces of broccoli sprouts every day for two months may protect against H pylori. They did note that the levels of a very specific byproduct called HpSA released by H pylori, had decreased by 40% in the stool of these patients but reappeared after they stopped the broccoli sprouts two months later. This indicates that broccoli sprouts prevent full colonization but by themselves, don’t eradicate the bacterium. I don’t know about you, I would choose broccoli sprouts over a proton pump inhibitor. Nexium also does not often eradicate H pylori and comes with a host of other side effects.
In earlier animal studies performed at Johns Hopkins University, mice infected with H pylori ate broccoli sprout smoothies for eight weeks daily. The H pylori in their stomachs decreased by 100 fold while there was a concomitant four fold increase in enzymes like sulforophane that protect against oxidative damage!
In another study published in 2004, consumption of oral broccoli sprouts was temporarily associated with eradication of H pylori infection in only three out of nine patients.
It looks like it may be more ideal to prevent rather than ridding yourself of the bug, so what else can you do?
OTHER NATURAL ALTERNATIVES YOU WONT HEAR FROM YOUR DOCTOR
My best advice is to pair some of these options with daily broccoli sprouts
- Pau D’Arco: This South American leaf also revs up the NRF-2 pathway just like broccoli sprouts! The results of a 2014 study published in the Journal of Toxicological Sciences found that the activation of NRF-2 could mediate the beneficial effects of Pau D’Arco in the intestine and with inflammation. It is also antibacterial, antiviral and anti fungal. It is known to fight candida and cancer. That is one of the main reasons I chose to put it in Microbiome Master, which has been successful at eradicating antibiotic resistant H Pylori in a handful of patients.
- Cranberries: This fruit is native to North America and has been shown to keep H pylon at bay. They work by preventing bacteria from adhering to cell walls-like in the bladder or stomach, hence why they are known for treating urinary tract infections. This is also why they are beneficial in preventing H pylori from taking hold in the stomach mucosa. In one study, a 90 day trial of cranberry juice compared to placebo in 189 patients, exhibited an increase in eradication rates of H pylori.
- Garlic: Garlic and its active ingredient, Allicin, produce organosulfphur compounds that deter oxidative damage by scavenging free radicals. Allicin is also revered for its potent antibacterial activity. Again this is another reason garlic was chosen for my gut cleanse, Microbiome Master.
- Curcumin: Although In-vivo tests in humans are lacking, one study did show benefit for long term cucurmin, the active ingredient in turmeric, in aiding in healing peptic ulcers and possibly, H pylori. Ulcers measuring up to 1.5cm were found in the duodenum of the stomach were treated with 300mg, five times a day of turmeric. 4 weeks of treatment revealed no ulcers in 48%. After 12 weeks, 76% had no ulcers!
- Ginger: Ginger has been used for centuries for ailments like nausea and dyspepsia due to its anti inflammatory and anti ulcer properties. Ginger has been shown in one study to restrict the growth of H pylori by inhibiting hydrogen and potassium released for gastric acid secretion. Gingerols and extracts, present in ginger, inhibit the development of H pylori in vitro in 19 clinical strains.
- Pistachia or Mastic Gum: This gum is produced by the Pistachio lentiscus plant in the Greek isles. It has been studied since the 1980s for its positive effects on the ulcers and stomach ailments. Mastic gum seems to work by inducing protrusions, or poking holes, in the cells of H pylori! A 2011 study proved that mastic gum prevents H pylori inflammation by inhibiting our white blood cells’ reaction in vivo. However, other animal and human studies have not replicated these findings.
- Artemisinin: This antimalarial drug has shown remarkably strong activity against H pylori infections. It was proven to have activity in vivo in a study published in 2012
- Zinc/Probiotics/Digestive Enzymes: Since H pylori is able to take hold of us due to lowered immunity, anything that helps us reset the bacterial balance and digestive properties in our guts will aid in an immune boost and also help fight this bacteria. Probiotics help to tip the bacterial balance in a favorable manner so that the improper bacteria can be recognized and disposed of. Digestive enzymes should not be supplemented forever but do help the body breakdown nutrients especially if the pH or digestion is off. Zinc works in tandem because it is necessary to help produce hydrochloric acid, which triggers our own natural digestive enzymes. Zinc also works to protect the stomach lining. It helps in wound healing and is anti inflammatory.
Check out my Microbiome Master in the Dr Jess which has eradicated H pylori in antibiotic resistant patients before!
You are becoming your own best doctor!
- Zhang L, Ma J. Pan K, Go VL, Chen J., You WC Efficacy of cranberry juice on Helicobacter pylori infection: a double blind, randomized placebo controlled trial. 2005; 10:139-145
- Shmuel, H. Domniz, N. Yahav J Non-Pharmacological treatment of Helicobacter pylori: World Journal of Gastrointestinal Pharmacology and Therapeutics
- Prucksunand C, Indrasukhsri B, Leethochawalit M, Hungspreugs K, Phase II clinical trial on effect of the long term turmeric on healing of peptic ulcer. Southeast Asian J Tropical Medical Public Health 2001: 208-215
- Malady GB Pendland SL, Yun GS, Lu ZZ, Soia A, Ginger and the ginger’s inhibit the growth of Cag A+strains of Helicobacter pylori. Anticancer Research. 2003: 23: 3699-3702
- Goswami S, Bhakuni RS, Chinniah A, Pal A, Kar SK, Das PK Anti-Helicobacter pylori potential of artemisinin and its derivatives. Antimicrobial Agents in Chemotherapy 2012