I never would have believed some of the things I’ve witnessed with patients. Because I choose to listen to them and believe them, I was able to help so many more people. And the more patients I see, the more I’m convinced we have a tangible reason for mood disorders like anxiety and depression. Moreover, I think we can extrapolate that cause to neurodegenerative conditions, like Alzheimer’s, Parkinson’s and ALS. Recent studies are now linking mood disorders and neurodegenerative conditions to inflammation, rather than neurotransmitter imbalances as previously thought. That former hypothesis sold the hell outta some SSRI antidepressants, but unfortunately it did not make them work any better. Up to 50% of patients experience refractory depression that is unsuccessfully treated by SSRIs. So where is the inflammation coming from? What is the root cause?
In my professional opinion, it is biotoxin illness in many cases. Under-diagnosed and overlooked by mainstream medicine, I have seen it cause enough inflammation to elicit mini strokes (transient ischemic attacks)and pericarditis. Refer back to my blog here https://drjess.com/all-about-mold-and-beyond-is-biotoxin-illness-the-missing-link-in-your-chronic-health-puzzle-2/ to find out what biotoxin illness is and if you should be checked out due to your symptoms.
Biofilm Disease, Stealth Infections, Traumatic Brain Injuries, and Psychiatry
Inflammatory markers are well-documented in psychiatric literature. Stealth infections, like candida, herpes, mold, Lyme and its co-infections, can all elicit rampant inflammation and fatigue in the body by disrupting cytokine function and spinning the hypothalamus-pituitary-adrenal (HPA) axis down, respectively. This is usually the first step in the CIRS biotoxin timeline—-chronic fatigue and anxiety. This then snowballs into androgen deficiency, immune dysfunction, even and mood disorders. Since biotoxins hide in the lymph and mucous membranes, they often affect the gut and digestive function. LEAKY GUT, LEAKY BRAIN. The reverse is also true-traumatic brain injuries (TBI) have shown us that a brain injury can also elicit leaky gut. The two are bi-directional. TBI appears to act upon the transmembrane proteins responsible for creating the intracellular scaffolding necessary to maintain tight junctions between intestinal epithelial cells. In one study, the transmembrane proteins ZO-1 and occludin were measured after a TBI to determine intestinal permeability. TBI caused a significant increase in intestinal permeability within 6 hours after injury, as marked by the decreased expression of ZO-1 and occludin, by 49% and 73%, respectively.
Research has shown that the microglia, or immune cells in our central nervous system, are persistently activated by head injury and that is highly associated with neurodegeneration as well as bipolar disorder. That being said, cytokines have been shown to increase the permeability of the blood-brain barrier membrane and the tight junctions in the gut. There’s several ways it can happen. Inflammatory cytokines like IL-1, IL-6 and TNF, MMP9 and TGF-beta; as well as bacterial toxins and by products, (lipopolysaccharides, LPS) have all been associated with increasing the permeability of the brain and gut lining. Talk about some brain fog and bloating…..and thats just the beginning. I’m going to attempt to connect this cascade to the beginning of a neurodegenerative condition, like Alzheimer’s disease here.
As I mentioned in my previous blog on mycotoxins, 25% of the population has a genetic haplotype that predisposes them to persistent CIRS. If you add up everyone in the United States thats been diagnosed with a psychiatric illness it’s around 20%. This might be coincidental, but scientific evidence throughout history indicates otherwise.
Mood Disorder or Undiagnosed Infection?
Consider that Lyme disease, which plagues more people than breast cancer, can cause psychiatric symptoms like depression, seizures, and suicidality. Lyme is caused by a spirochete, a bacteria which is corkscrew shaped. This means it can burrow into tissues like the brain, mucous membranes and other parts of the neurologic system. It is a cousin to syphilis, which is rumored to have been the psychiatric downfall of Napoleon. They behave very similarly and are experts at hiding from the immune system by forming a sticky biofilm that acts a wall against the body’s defenses. Mold is known to cause personality changes, depression, anxiety and chronic fatigue. In fact, in one study, they surveyed 6000 Europeans and found moderately higher depression (up to 40%) in those that lived in visibly moldy houses. Clostridium, the gram positive anaerobic bacteria, is implicated in schizophrenia and autism in some patients. Its also connected to addictive behavior. Bartonella, or cat scratch fever, is another tick associated illness linked to ice pick headaches, neurologic symptoms and rage episodes. PANDAs, the neuropsychiatric illness that appears in children, is thought to be triggered by Streptococcus and can present as outbursts, obsessive-compulsive behavior and anxiety. Some of the literature showed active HHV-6 in the autopsied brains of depressed patients and patients diagnosed with bipolar disorder.,
Whats truly interesting is that many of the immune markers that indicate biotoxin illness or CIRS, or chronic inflammatory response syndrome, also are indicative and suggestive of stark inflammation, including neuroinflammation. New studies are now linking mood disorders, like anxiety and depression, to neuroinflammation rather than blaming it all on genetics or imbalanced neurotransmitters. These markers include MSH, VIP, VEGF, TGF-beta 1, MMP9, C4a, ACTH/cortisol and ADH/osmolality and are linked to dysregulated hormonal, neuroendocrine, gastrointestinal and immune function. This is an all over-body, systemic attack (more of this to come). In fact, I believe this is the possessions spoke of in religious texts.
Speaking of possessions, some of the best evidence for this is in schizophrenia disorder. Schizophrenia is strongly correlated with toxoplasmosis, an obligatory parasite that invades the brain and can be contracted from cat litter boxes. Another study shows how inflammation and a higher incidence of Celiac disease, or gluten intolerance, is strangely found among schizophrenics. My opinion? Gluten has been adulterated from its natural version and feeds stealth infections which are the root cause of schizophrenia.
The Body Attacking Itself or Reacting to a Hidden Presence?
And thats just psychiatric conditions! But you better believe these infections can cause other chronic health issues. Many stealth infections are also connected to autoimmune conditions. A recent study out of Cincinnati connected Epstein Barr virus (EBV), a member of the herpes family, to seven different autoimmune conditions including multiple sclerosis, juvenile diabetes, and Celiac disease. It is well established that EBV is behind Burkitt’s lymphoma, nasopharyngeal carcinoma, some types of Bells Palsy and Guillain Barre syndrome.
Viruses are thought to elicit autoimmune conditions through complex processes including molecular mimicry, where the host and pathogen share a common immunologic epitope that ultimately confuses the body. Autoimmunity can also occur through bystander activation and an overzealous immune system, or by persistent stealth infections, that can re-activate throughout the life of the host, especially under opportunistic conditions. (i.e. stress).
An Answer for Alzheimer’s?
Alzheimer’s disease (AD) is the third cause of death in the United States and over 47 million people live with it globally. Alzheimer’s is characterized by the accumulation of amyloid plaques and neurofibrillary tangles between the neurons in the brain.
Alzheimer’s disease type 3 has been found to be a direct result of exposure to certain toxins that accumulate overtime and begin to degrade the brain. Inhalational Alzheimer’s, or type 3 Alzheimer’s Disease lab results can present similar to chronic inflammatory response syndrome (CIRS) patients. However, their symptoms will look more like AD dementia rather than mold toxicity. In this study done in 2010, the researchers link higher levels of inflammatory cytokines which affect the brain to AD. Yep in the cerebrospinal fluid, they found all the usual markers of CIRS-TGF beta, IL-1, IL-6 and tumor necrosis factor.
A 2014 study found fungal macromolecules in the brains of Alzheimer’s patients, directly supporting categorization of type 3 AD. Additionally, a 2015 study found fungal infections in brains of 10 Alzheimer’s patients further supporting the fact that mold can cause Alzheimer’s disease. The most recent study published in the journal Aging in 2016, directly correlated CIRS as well as heavy metal exposure, to the cause of type 3 Alzheimers disease. The jury is in: MOLD CAN CAUSE ALZHEIMER’S.
“Ochratoxin, an aflatoxin produced by the insidious black mold, Aspergillus, depletes striatal dopamine, which is highly associated with movement disorders like Parkinson’s. It also depletes the hippocampus, which is where our memory are stored. That’s good evidence that ochratoxin will be damaging the parts of the brain associated with mood and movement disorders, to produce longterm effects.” (4) Ask anyone with mycotoxin or biotoxin illness, and they’ll sympathize with the severe brain fog and inability to think clearly. Many even say they understand how it can be fully bloom into a neurodegenerative condition like AD.
The truth is that many more infections besides mold, have also been found in the autopsied brains of Alzheimers patients, which likely can contribute to the quality and severity of the condition.
“The increasing number of reports of various pathogens identified in the brains of patients with Alzheimer’s disease—from viruses such as Herpes simplex to oral bacteria such as P. gingivalis  to fungi such as C. glabratus —raises the possibility that what is referred to as Alzheimer’s disease may actually be the result of a protective response to various brain perturbations.”
It seems that our bodies are always trying to protect us, even if its to our demises. In my opinion, the toxicities of the environment lead to lowered immunity and predispose us to collective infestations. There is a root cause!
Biotoxin Illness-getting on Top the Brain-Adrenal Axis is the First Step
I mentioned above that chronic fatigue and anxiety are usually the first symptoms a patient who is developing biotoxin illness will likely feel. Why? Normally, when a person comes in contact with a biotoxin-producing organism, the immune system is able to bind, tag and remove it effectively. In CIRS, antigen-antibody recognition becomes impaired. The consequences of that are continual and improper activation of the cytokine response AKA inflammation. The overactive innate immune system, coupled with a dysfunctional adaptive immune system leads to multifaceted and multi-systemic disease syndrome.
Figure of the correct relationship between the hypothalamus and pituitary and the adrenal glands
Figure of the inflammation cascade activated by CIRS
The first symptom is often fatigue, no matter how much one sleeps. At first some patients may feel “wired but tired,” as the body tries one last hoorah to surge cortisol and fight the infection. Eventually the talk between the brain and the adrenals bottoms out, leading to low cortisol (and a higher risk for autoimmune conditions since cortisol is responsible for tagging autoimmune cells for destruction and removal from the body). This inflammation can build over time. Occasionally the body gets a glimpse of the invader and increases the cytokine and inflammation cascade. This can be a risk factor for transient ischemic attacks or mini strokes as well as pulmonary emboli and heart attacks. Keeping the blood thin with fibrinolytic enzymes during this time is advised.
Another risk factor for early burnout and adrenal dysfunction is adverse childhood events (ACE). Studies have routinely demonstrated that the more ACEs you have, the higher the risk of disease and autoimmunity. In fact, compared with persons with no ACEs, persons with ≥2 ACEs were at a 70% increased risk for hospitalizations with Th1 autoimmune conditions, 80% increased risk for Th2 autoimmune conditions, and 100% increased risk for rheumatic diseases (p < .05).
In this study they correlated childhood abuse with major depressive disorder later in life. What does all of this mean?
Unfortunately, our brains are still malleable as children. Stress incurred at a young age is relevant! Abuse ingrains certain neuronal firing, responses, cortisol levels and increased inflammation through cytokine activation in the microglia of the brain.
The next step in taking over your body is androgen deficiency and then eventual melatonin disruption and immune dysfunction. Recall and executive function is relatively impaired. .
Mold, Biotoxin Illness and Mood Disorders: Neurotransmitter Pathways
Any pathogen with a biofilm has the potential to take over the body insidiously, but most have their signature abnormalities with neurotransmitters.
For example, Clostridium, linked to addictions, aggression and even autism and schizophrenia, works by inhibiting the breakdown of tyrosine, the precursor to dopamine. It is the excitatory nature of this neurotransmitter that is responsible for the obsessive compulsive-like behaviors seen in autism. Dopamine oversees the reward-pleasure center as well as compulsion, so it is easy to see how this could spiral into addiction or overstimulation in some patients.
On the other end of the spectrum is Parkinson’s, which has too little dopamine, leading to rigidity, anhedonia and depression.
Chart from Great Plains laboratory-organic acids test
Not all hidden infections produce this picture though. Many produce lower amounts of serotonin due to inflammation. Serotonin controls mood, movement, immune function, and sleep. As you can see, tryptophan, the sleepy amino acid famously found in turkey, is the precursor to making serotonin, which is really important. Serotonin not only makes us happy, but goes on to make melatonin, so it ultimately helps us sleep too.
But if we have inflammatory cytokines present from trauma or infections like mold present, the pathway to make serotonin is not followed. Instead, the immune activation goes on to activate the kynurenine pathway and leads to making quinolinic acid. Quinolinic acid is strongly correlated to depression and suicide. It also degrades tryptophan. Quinolinic exerts its effects by antagonizing the glutamatergic, or excitatory pathway. It involves the NMDA receptors, which are associated with inflammation, psychosis actually, and probably suicide. It has been shown to be elevated in the cerebrospinal fluid of suicide victims. In fact, ketamine may exert anti-suicidal effects by counteracting the kynurenine metabolites
Chart showing the kynurenine pathway which produces the toxic quinolinic acid rather than serotonin
Multiple studies have indicated this pathway in depression and suicide. Novel approaches are currently looking at ways to treat mood disorders by understanding the activation of quinolinic acid and its metabolites. This is literally the inflammatory state associated with illness and is not controllable or psychologic.
We do have studies that show that CIRS/biotoxin illness can directly damage the brain. Dr Shoemaker, cited below, found people with elevated TGF-beta and MMP9 have frontal lobe, hippocampus and cerebellum edema or swelling. Dr Amen, a renown integrative psychiatrist, owns a clinic that has used SPECT imaging to display mycotoxin damage to the brain.
See below for some example of biotoxin-causing pathogens that can found in water damaged building exposure.
Table 1: Types of toxins, inflammagens and microbes associated with water damaged buildings
Aspergillus penicilloides Aspergillus versicolor, Wallemia sebi, Stachybotyrs chartarum, Chaetomium globosum
Mycotoxins, hyphal fragments, conidia, mannans, spirocyclic drimanes, Chitinases
Protozoa and amoebas
Gram negative bacteria, gram positive bacteria, mycobacteria, chlamydia, mycoplasma
Endotoxins, Lipopolysaccharides, Actinomycetes, Nocardia, Hemolysins
Siderophores, beta glucans, cell wall components, cell fragments, proteinases
Microbial VOC’s, building material VOC’s, inorganic xenobiotics
Bioaerosols, coarse particulates, fine particulates, ultrafine particulates, nano-sized particulates
Everyone is different so treatment should not be attempted unless under the guidance of a lyme literate doctor, or at the very least, one who is skilled in stealth infections like Lyme or Mycotoxins. Diagnosis can prove difficult for many patients, who end up being victims of the system until some savvy doc figures them out. Some go years, trying multiple antidepressants or antipsychotics to no avail. Some end up diagnosing themselves and seeking out treatment. Great plains lab has been an amazing aid to me in diagnosing stubborn cases.
Never miss another stealth infection patient by always screening with these questions:
- Have you been bit by a tick, bedbugs, mosquito or fleas which elicited an odd immune reaction, or rash, specifically a bullseye rash?
- Have you been exposed to a water damaged building or leak?
- Do you have brain fog, bloating, joint pains, rashes, headaches, sinus problems, eye floaters, electric shocks on the skin, ear ringing or difficulty holding your urine?
- Do you have ice pick headaches or pain on the soles of your feet?
- Do you have mood swings, frustration, addictions or rage episodes?
Again, treatment should be reserved individually for each patient and their specific diagnosis. However some of the mainstays from my treatment plan includes DHA, EPA, other fish oils, DHEA or glandular for adrenal support if needed, vitamin D, binders like activated charcoal, clays, apple pectin or my up and coming Binder Master, fibrinolytic, anti-herbals like my Microbiome Master or Biocidin. However, supplements or medicines only go so far. The proactivity of the patient in their everyday routine is most imperative. In my protocol, kill, bind, sweat for elimination as well as heat shock protein activation, occurs daily. Coffee enemas, colonics, IV ozone or ozone sufflations, hemp products, and lymph massages might also be employed on a case by case basis.. It is extremely important to ensure that the patient’s detox pathways are functioning properly.
As expected, a strict diet is necessary. Many patients will have already figured this out by trial and error by the time they come to see their practitioner. Remember the link between schizophrenia, anti-gliadin antibodies, and gluten? Eliminating gluten, which feeds neuroinflammation and other infections, is imperative. Its also helpful to get rid of processed dairy, factory farmed meats, soy, caged eggs, and SUGAR. An anti inflammatory diet protects the brain and the gut. High levels of healthy fats are highly encouraged.
Consider that Dr. Terry Wahls put her multiple sclerosis into remission eating more than 15 servings of vegetables a day, grass fed meats, weekly organ meats, wild caught fish and healthy fats.
Integrative programs, with multidisciplinary physicians working together, may be indicated. Patients may need psychotherapy or counseling to get past childhood trauma, which plays into their physical ailments. Moving may be indicated if mold is found, and this can be a roadblock for healing in some cases. Patients may also require mainstream medical interventions or drugs occasionally. All of this is to be expected in the realm of healing.
Expect at least a 3 month treatment plan for biotoxin illness, and often longer depending on how indolent the infection is. The truth is that you can heal and feel human again. This is a possession. Reclaim your life.